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KMID : 1098420070150060411
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 6 p.411 ~ p.416
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Toxicity Reduction and Improvement of Anticancer Activities from Rhodiola sachalinensis A. Bor by Ultra High Pressure Extracts Process
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Kim Cheol-Hee
Kwon Min-Cheol
Qadir Syed Abdul
Hwang Baik
Nam Jong-Hyeon
Lee Hyeon-Yong
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Abstract
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This study was performed to investigate the reduction of toxicity and improvement of anticancer activities from R. sachalinensis by ultra high pressure extracts process. The cytotoxicity on human kidney cell (HEK293) and human lung cell (HEL299) was showed below 20.4% and 21.6% as compare to normal extracts in adding 1.0 concentration. This showed that toxic materials through ultra high pressure processing is broken or degraded. Because bond such as hydrogen bond, electrostatic bond, Van der waals bond, the hydrophobic bond, can be broken by high pressure. The anticancer activity was also increased in over 7% by high pressure processing in A549, AGS, MCF-7 and Hep3B cells. The result showed that extraction by high pressure have low cytotoxicity and high anticancer activity. So, the high pressure extraction technology can play an important role in eruption of new material with high biological activity.
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KEYWORD
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Rhodiola sachalinensis, Ultra high pressure, toxicity reduction, anticancer activities
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